COEXISTENCE OF ADRENOCORTICOTROPIN AND SECRETOGRANIN ⅡIN THE RAT PITUITARY GLAND AFTER BRAIN INJURY / 神经解剖学杂志
Chinese Journal of Neuroanatomy
;
(6): 337-340,55, 2000.
Artículo
en Chino
| WPRIM
| ID: wpr-582561
ABSTRACT
The localization of adrenocorticotropin(ACTH),secretogranin Ⅱ in rat pituitary gland Was studied by using specific antisera in conjunction with double immunofluorescence staining techniques.Stainings with secretogranin Ⅱ serum showed intense cytoplasmic reaction in the anterior lobe of the pituitary gland.Double immunofluorescence staining was used to identify the cells that expressed secretogranin Ⅱ and ACTH.Confocal laser scanning microscopy revealed that ACTH existed simultaneouslywith secretogranin Ⅱ in quite a number of cells.The results indicate that secretogranin Ⅱ is expressed in corticotrophs of rat pituitary gland,its physiological role may be associated with the regulation of optimal pH in the secretory vesicles for the cleavage of ACTH from its precursor.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Neuroanatomy
Año:
2000
Tipo del documento:
Artículo
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