Preventive and protective effect of CGRP on focal cerebral infarction in rats / 临床神经病学杂志

ABSTRACT

Objective To explore the preventive and protective effect of CGRP on focal cerebral infarction in rats.Methods Focal cerebral infarction model was made by photochemical reaction. The level of cerebral edema was assayed by measuring brain water content.Nervous system evaluation was scored by the method of Ohno, Bederson, LeWay standard. The volume of cerebral infarction and its location were determined by TTC staining.Results CGRP has significant preventive and protective effect to focal cerebral infarction which showed the nervous system scores took a favourable turn, brain edema descended and infarction volume reduced. This effect was related with the dose and the way of administration of CGRP. A single dose (1.33 BU/gBW) of CGRP didn't have significantly effective.It should be given for at least over 2 days. This protective effect did not increase when the dose increased to a certain level. As for the effect of the way of administration of CGRP, multiadministration of fewer doses CGRP was better while the total dose kept constantly.Conclusion CGRP has definite preventive and protective effect to focal cerebral infarction in rats.It has also better effective in inhibition of brain edema. However its dose should be confined in a proper level.