Effects of transplanting bone marrow cells on cardiomyocyte apoptosis and expressions of Bcl-2 and Bax in post-infarction rats / 中国介入心脏病学杂志
Chinese Journal of Interventional Cardiology
;
(4)2003.
Artículo
en Chino
| WPRIM
| ID: wpr-584197
ABSTRACT
Objective To clarify the role of cardiomyocyte apoptosis in cardiac function after transplantation of bone marrow cells. Methods A mycardial infarction model was induced in SD rats by left anterior descending artery ligation. 5?106 of bone marrow mononuclear cells were injected into peri-infarct zone (BMT group). In 4 or 8 weeks post-infarct, apoptosis of cardiomyocytes and expression of Bcl-2/Bax protein were determined by TUNEL or immunohistochemistry. Cardiac function was evaluated by echocardiography (UCG). Results TUNEL results indicated that apoptosis index of peri-infarct zone from the BMT group was reduced significantly when compared with the control group (4 wk 0.094?6?0.017 vs 0.173?0.018, P
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Interventional Cardiology
Año:
2003
Tipo del documento:
Artículo
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