Antioxidative activity of polysaccharide fraction from Por-phyra haitanensis on oxidative stress in mice irradiated by 60Co / 中国海洋药物

ABSTRACT

Sulfated polysaccharide from Porphyra haitanensis showed inhibitory effect on the lipid peroxidation in vitro. In the present study, the changes in the antioxidative enzyme activity, lipid peroxidation, and total antioxidative capacity (T-AOC) in different organs after 60 Co irradiation were detected in mice by using biochemical methods. Increased endogenous lipid peroxidation and decreased contents of T-AOC as well as decreased activities of super-oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were observed in mice after 60Co irradiation. Intraperitoneal administration of polysaccharide fraction F2 significantly decreased the lipid peroxidation. F2 treatment increased T-AOC and the activities of SOD and GSH-Px in all organs tested in 60Co irradiated mice. It is concluded that the sulfated polysaccharide fraction F2 from Porphyra haitanensis can be used in compensating the decline in antioxidative capacity arising from radiotherapy and thereby reduced the risks of lipid peroxidation.