Recent progress in molecular pathogenesis of B-cell lymphoma / 医学研究生学报

ABSTRACT

B-cell lymphomas(BCL) are the most frequent types of lymphoma and encompasses different entites with variable clinical behavior and diverse molecular features. In general terms, it can be subdivided into 2 main groups, low- and high-growth fraction lymphomas. In low-growth fraction lymphomas, cell accumulation can be achieved through the inhibition of apoptosis without a very severe deregulation of cell proliferation. In contrast, high-growth fraction BCL are characterized by an enhanced proliferative activity, as a result of the deregulation of oncogenes with cell cycle regulatory functions, such as Bcl 6 and c-myc. A fraction of both low- and high-growth lymphomas acquire additional alterations in cell cycle control, usually involving cyclin-dependent kinase inhibitors and evolve to highly aggressive tumors.