Transforming growth factor-?Smad4 signaling pathway in carcinogenesis / 医学研究生学报

ABSTRACT

The transforming growth factor-?(TGF-?)-Smad signaling pathway has an important role in carcinogenesis. In recent years, some investigations have revealed the functions of TGF-? super-family ligands, receptors, Smads protein, up stream and down stream regulators and cross-talk among many signaling pathways in gastrointestinal cancers, lung cancer and other cancers. This review attempts to collate and integrate the extensive body of in vivo and in vitro studies about TGF-?-Smad signaling pathway and Smad4 in cancers.