Animal model of complex partial epilepsy caused by simultaneous kindling of bilateral amygdala / 临床神经病学杂志

ABSTRACT

Objective To observe the characteristics and onset time of seizures caused by kindling of bilateral amygdale, and to discuss its mechanism.Methods 40 adult Wistar rats were randomly assigned into bilateral amygdala kindling group and unilateral amygdala kindling group. The models were made according to Goddard's method. Results All the rats in bilateral amygdala kindling group developed stage Ⅴ convulsions after a mean of 20.9 stimulations.12 rats of which showed spontaneous seizure discharges. But in unilateral amygdala kindling group, the successful kindling rate was 60% after a mean of 8.9 stimulations. Comparing with unilateral kindling, bilateral amygdala kindling significantly increased the successful rate of kindling (P