Effects of indole-2,3-dione on the content and release of monoamine neurotransmitters in rat brain / 中国海洋药物
Chinese Journal of Marine Drugs
; (6)1994.
Article
en Zh
| WPRIM
| ID: wpr-584978
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study the effect of indole- 2,3-dione on the content and release of monoamine neurotransmitters in rat brain.Methods The Wistar rats were given indole-2,3-dione (50,200mg?kg~(-1),ip), and the content of acetylcholine(Ach) and dopamine(DA) in corpus striatum were detected two hours later;the releases of DA,5-hydroxy-tryptamine(5-HT) and norepinephrine(NE) in cortex and corpus striatum slices were examined before and after perfusion with the artificial cerebrospinal fluid(ACSF)that contained indole-2,3-dione. Results The rats given indole-2,3-dione were observed higher concentration of Ach and DA in their corpus striatum compared with that in cortex. Moreover the results also showed indole- 2,3-dione promoted the release of DA in cortex and corpus striatum slices. Conclusion Indole-2,3-dione can regulate the balance between Ach and DA release in rat brain.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Marine Drugs
Año:
1994
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Article