Clinical implication of Dendritic Cell Infiltration in Cervical Tuberculous Lymphadenitis / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 523-531, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-58669
ABSTRACT
BACKGROUND:
Cervical tuberculous lymphadenopathy is a very common disease with a similar incidence to pulmonary tuberculosis. Dendritic cells play a role of initial antigen presentation of this illness. Nevertheless, the precise role of these antigen-presenting cells according to the clinical features in unclear. The aim of this study was to determine the clinical implication of dendritic cell infiltration in the cervical lymph nodes.METHODS:
A review of the clinical characteristics was carried out retrospectively based on the clinical records and radiography. Immunohistochemical staining was performed on the available histology specimens of 72 cases using the S-100b polyclonal antibody for dendritic cells. The number of dendritic cells with tuberculous granuloma were determined. A x2 test, unpaired T test and multiple logistic regression analysis were performed.RESULTS:
Thirty percent of subjects had previous or concurrent pulmonary TB. Twenty one percent of cases showed a positive reaction on the AFB stain. Within a granuloma, the number of infiltrated dendritic cells was 113.0+/-7.0. The incidence of fever and cough decreased with increasing infiltration of dendritic cells Multivariate regression analysis showed that the infiltration of dendritic cells could significantly contribute to fever.CONCLUSION:
Overall, dendritic cells can control a Mycobacterium tuberculosis infection and modulate the immune response, as well as resolve the clinical manifestations of TB lymphadenopathy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tuberculosis
/
Tuberculosis Ganglionar
/
Tuberculosis Pulmonar
/
Células Dendríticas
/
Radiografía
/
Modelos Logísticos
/
Incidencia
/
Estudios Retrospectivos
/
Presentación de Antígeno
/
Tos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Año:
2006
Tipo del documento:
Artículo
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