Dynamic Analysis of TGF-β1 Gene Expressions in Bleomycin-Induced Pulmonary Fibrosis in Rats by RT-PCR / 中国医科大学学报
Journal of China Medical University
;
(12): 94-95,100, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-588137
ABSTRACT
Objective:
Our aim was to evaluate the role of TGF-β1 mRNA in pulmonary fibrosis.Methods:
The present study was taken to investigate the expressions of TGF-β1 mRNA in alveolar macrophage(AM) and lung tissues in different stages of bleomycin-induced pulmonary fibrosis in rats through reverse transcript polymerase chain reaction.Results:
In bleomycin-treated rats, the expressions of TGF-β1 mRNA was remarkably increased in AM from 3rd day (P< 0.05) , and reached the peak on 7th day (P<0.01) , there was also a continuing high level from 14th day to 28th day (P>0.05). It showed similar pattern with that in lung tissues.Conclusion:
There were TGF-β1 mRNA expression in both normal rats and pulmonary fibrosis rats. AMs seemed to be the main source of TGF-β1 mRNA in lung tissues, especially at stage of alveolitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of China Medical University
Año:
2001
Tipo del documento:
Artículo
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