Imipenem Resistance Mechanisms in Pseudomonas aeruginosa / 中华医院感染学杂志
Chinese Journal of Nosocomiology
; (24)1994.
Article
en Zh
| WPRIM
| ID: wpr-588208
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE To study the mechanisms of imipenem resistance in Pseudomonas aeruginosa.METHODS PCR method was used to detect and analyze P.aeruginosa imipenem-resistance associated IMP gene and VIM gene of metallo-?-lactamases and outer membrane protein D2(OprD_2) gene.RESULTS All 35(imipenem)-resistant P.aeruginosa strains were negative for IMP gene and VIM gene of metallo-?-lactamases;and for OprD_2 gene;but 23S rRNA gene of all 35 P.aeruginosa strains was positive.CONCLUSIONS The study suggested that in(Xiangfan) area,Hubei Province P.aeruginosa doesn′t produce metallo-?-(lactamases),but in genetics it is(identified) that the loss of outermembrane protein D2(OprD_2) gene is the(essential) mechanisms of imipenem(resistance) in P.aeruginosa in Xiangfan area,Hubei Province.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Nosocomiology
Año:
1994
Tipo del documento:
Article