The effect of injection rate on etomidate-induced myoclonus / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 305-307, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-58983
ABSTRACT
BACKGROUND:
Etomidate frequently causes myoclonus. Since the myoclonus is caused by a transient disequilibrium due to etomidate exposure in the CNS, we hypothesized that a slow rate of injection of the drug may decrease the incidence of myoclonus. We conducted a prospective randomized study to compare the effect of two different types of the etomidate injection rate on the incidence and severity of myoclonus.METHODS:
Fifty patients were randomly assigned to the fast-injection group (group F) or slow-injection group (group S) Group F patients received etomidate (0.3 mg/kg) over ten seconds. The same dose was administered over two minutes for group S patients. The response to the injection of etomidate was graded on a four-point scale in a blinded manner. The time to loss of consciousness (LOC) was also recorded.RESULTS:
The incidence of myoclonus was significantly lower (P < 0.001) in group S patients; 84% and 28% in group F and group S patients, respectively. The myoclonus was also significantly less severe in group S patients (P < 0.001). The time to LOC was significantly longer in group S patients (106 +/- 22 sec) than that of group F patients (49 +/- 18 sec, P < 0.001).CONCLUSIONS:
With same dose, a slower rate of injection resulted in a lower incidence of myoclonus and can effectively reduce myoclonus without the use of a pretreatment agent.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Inconsciencia
/
Incidencia
/
Estudios Prospectivos
/
Etomidato
/
Mioclonía
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Anesthesiology
Año:
2008
Tipo del documento:
Artículo
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