Changes of plasma ANP and BNP in plasma before and after percutanous balloon mitral valvuloplasty / 中国介入心脏病学杂志

ABSTRACT

Objective To observe the changes of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in plasma and the correlation of ANP and BNP with hemodynamic parameters in patients with sinus rhythm or atrial fibrillation after percutanous balloon mitral valvuloplasty (PBMV). Methods Thirty-six patients with rheumatic mitral stenosis undergoing first time successful PBMV were enrolled in the study. Among a total of 36 patients, 11 were in sinus rhythm (SR group) and 25 had atrial fibrillation (Af group). The levels of ANP and BNP were assayed before and at 1 day and 3 days after the procedure. Hemodynamic parameters were measured by echocardiography and left atrial pressure (LAP) and pulmonary artery pressure (PAP) were assessed instantly by cardiac catheter before and after PBMV. Results After PBMV,the ANP levels gradually decreased (216.09?73.84 pg/mL; 188.70?59.22 pg/mL; 140.70?41.53 pg/mL, respectively, before, at one day and three days after procedure, P