Th17 cell and CD4 + CD25 + Treg in iathogenesis of asthma / 国际儿科学杂志
International Journal of Pediatrics
; (6): 196-198,202, 2012.
Article
en Zh
| WPRIM
| ID: wpr-590343
Biblioteca responsable:
WPRO
ABSTRACT
Many studies have suggested that pathogenesis of asthma could no longer be interpreted merely by “Th1/Th2 balance” theory.CD4 + CD25 + Treg and Th17 cells,as well as their cytokines such as IL-10,transforming growth factor-β,and IL-17,account for asthma.CD4 + CD25 + Treg and Th17 are functionally antagonistic to each other,and also go with each other during their differentiation.Therefore,immunity-unbalance of CD4 + CD25 + Treg and Th17 is one of the most important factors that triggers asthma.Glucocorticoid has been shown to down regulate IL-17 expression by retinoic acid receptors γt signaling pathway,and regulate differentiation and function of CD4 + CD25 + Treg by inducing expression of transcription factor Foxp3,all of these are immuno-mechanisms of glucocorticoid in asthma treatment.
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WPRIM
Idioma:
Zh
Revista:
International Journal of Pediatrics
Año:
2012
Tipo del documento:
Article