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Antibacterial Activity of Allicin Combined with Cefoperazone Against Pseudomonas aeruginosa / 中华医院感染学杂志
Chinese Journal of Nosocomiology ; (24)2006.
Artículo en Chino | WPRIM | ID: wpr-590425
ABSTRACT
OBJECTIVE To study the in virto interaction of allicin combined with cefoperazone against clinical isolates of Pseudomonas aeruginosa.METHODS The protocol was designed by checkerboard method and the MICs of allicin combined with cefoperazone against the 17 strains of sensitive and 14 strains of drug-resistant P.aeruginosa were determined by broth dilution method,the FIC index was calculated according to MIC results.The combined effects were confirmed by FIC index.RESULTS The percentage of the FIC index less than 0.5,from 0.5 to 1,from 1 to 2,and more than 2 was 41.2-64.3% 35.7-41.2% 0-17.6%,and 0%,respectively.CONCLUSIONS Synergism and additivity of allicin combined with cefoperazone against P.aeruginosa are their main action,there are little autonomy and no antagonism.Allicin can significantly improve the antibacterial activity of cefoperazone against drug-resistant P.aeruginosa.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Guía de Práctica Clínica Idioma: Chino Revista: Chinese Journal of Nosocomiology Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Guía de Práctica Clínica Idioma: Chino Revista: Chinese Journal of Nosocomiology Año: 2006 Tipo del documento: Artículo