Treatment of Acne with Isotretinoin in a Patient with Apert's Syndrome / 대한피부과학회지

ABSTRACT

Apert's syndrome is a rare autosomal dominant disease that's characterized by craniosynostosis and severe syndactyly of both the hands and feet. It is caused by a mutation of the fibroblast growth factor receptor (FGFR) type-2 gene. The development of widespread acne, involving the face, chest, back and forearms, is a characteristic finding at puberty in Apert's syndrome patients. The acne of Apert's syndrome patients is generally resistant to conventional therapy, including topical agents and/or oral antibiotics, but it shows a good response to isotretinoin. We report here on a case of acne that was successfully treated with isotretinoin in a teenager with Apert's syndrome.