Pathogens Distribution of Hospital Infection and Their Drug Resistance in Department of Orthopedics / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To evaluate the pathogens in department of orthopedics infection and the bacterial resistance to antibiotics,and to provide reference of clinical antibiotic therapy.METHODS A total of 603 pathogenic strains isolated from patients with bone and joint purulent infection,from Apr 2004 to Apr 2007 were retrospectively analyzed with the results of their bacterial cultures and antibiotics sensitivity tests by VITEK32,a part of antibiotics sensitivity tests by K-B and Etest.RESULTS The inspection rate of Pseudomonas aeruginosa,Staphylococcus aureus,S.haemolyticus,S.epidermidis,and Acinetobacter baumannii were 17.08%,14.76%,12.94%,12.27% and 9.65%,respectively.Meticillin-resistant S.aureus(MRSA)was higher than 60.00%,pathogen rate of Gram-positive cocci,Gram-negative bacteria,and Candida were 47.76%,43.78%,and 7.96%,respectively.Staphylococcus were major pathogens of bone and joint purulent infection,multidrug-resistant Staphylococcus infections have increased.CONCLUSIONS Bone and joint purulent infection is mainly caused by Staphylococcus which resist to many antibiotics,A.baumannii and P.aeruginosa are also often found these years.Routine blood culture before using of antibiotics should be taken.The sensitive antibiotics are selected and adjusted according to the results of blood culture and sensitivity test.