Diagnostic value of combined detection of serum AFU and AFP in predicting recurrence in patients with liver cancer / 肿瘤研究与临床

ABSTRACT

Objective To explore the value of the combined detection of serum AFU and AFP on predicting postoperative recurrence of hepatocellular carcinoma. Methods Three groups were classified as pathological observation group, pathological control group and health control group. AFU was detected by ratio colorimetric method with the AFU>40 U/L defined as positive values. AFP was detected by microparticle enzyme immunoassay with AFP> 13.6 μg/L defined as positive values. Results AFU and AFP level of the pathological observation group were significantly different compared with the pathological control group and health control group(P <0.001). AFU and AFP level of the pathological control group were higher than those in the health control group, but no significant difference (P >0.05). For the pathological observation group, the level of AFU and AFP after recurrence were significantly different than that before (P <0.001). As to the sensitivity and accuracy of method, AFU + AFP and AFU or AFP were significantly different (P <0.001). There was no significant difference between AFU and AFP(P >0.05). As to the specificity of method, there was no significant differences among AFU+AFP, AFP and AFU (P >0.05). Conclusion The combined detection of serum AFU and AFP levels significantly raised the diagnostic value of liver cancer recurrence. They may applied as a predictor or indicator of postoperative recurrence of hepatocellular carcinoma.