Immunotolerance following intermingled skin transplantation / 中国组织工程研究

ABSTRACT

PUBMED Database and Vip Database were undertaken to identify relevant articles on intermingled skin transplantation. Skin cuticular layer consists of keratinocytes and dendritic cells (DCs), so the researches on intermingled skin transplantation includes the chimerism of allo-keratinocyte and the chimerism of allo-DCs. There is no study about the chimerism of allo-DCs at present. The investigations on skin microchimerism are limited to the immunotolerance induced by exogenous stem cell transplantation, and the microchimerism phenomenon has not been found in allo-skin transplantation and intermingled skin transplantation. Regulating T cells, Th3 cells and NKT cells play important roles in the induction of the immunotolerance after intermingled skin transplantation.