Evaluation of bioavailability of ketoprofen 200 mg long acting tablets

ABSTRACT

In vitro bioavailability of ketoprofen 200mg long acting tablets by the oral were studied. Using basket dissolution tester at 120rpm. Released ketoprofen was determined by a UV – spectrophotometer at 260nm. Ketoprofen plasma levels on carefully chosen 6 healthy volunteers were within treatment which reached from 4 to 36 hours. 200mg ketoprofen LP tablets gradually released ketoprofen within 24 hours and released about 80% after 18 hours. Pharmacological parameter of ketoprofen 200mg long acting tablets have the same value compared with the results which have been published