Association of LCT-13910 C/T Polymorphism and Colorectal Cancer
Annals of Coloproctology
; : 169-172, 2017.
Article
en En
| WPRIM
| ID: wpr-59260
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The activity of epithelial lactase (LCT) is associated with a polymorphism 13910 bp upstream in the lactase encoding gene. Because the association between the LCT-13910 polymorphism and the risk for colorectal cancer is not clear, we investigated the role of the LCT-13910 polymorphism as a potential risk factor for colorectal cancer and colorectal polyps in the Turkish population. METHODS: One hundred sixty-six subjects (74 with polyps, 44 with colorectal cancer, 48 controls), who had undergone a total colonoscopy between January 2012 and November 2012 in our endoscopy unit were genotyped for the LCT-13910 polymorphism by using the polymerase chain reaction and minisequencing. RESULTS: The CC genotype in the lactose gene 13910 locus, which is accepted as the genetic indicator of lactase deficiency, was determined as 83.7%. The CC genotype rate was determined as 89.1% in patients who had a history of lactose intolerance and 81.5% in those without a history of lactose intolerance (P = 0.236). No difference was detected between the patients who had colorectal polyp(s) and/or cancer and the controls with regard to the LCT-13910 polymorphism. No differences were determined between groups when they were compared with regard to the C or the T allele. CONCLUSION: No differences were detected between the patients who had colorectal polyp(s) and/or cancer and those with normal colonoscopy findings with regard to lactase gene polymorphisms. No differences were determined between the groups when they were compared with regard to the C or the T allele.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pólipos
/
Neoplasias Colorrectales
/
Adenocarcinoma
/
Reacción en Cadena de la Polimerasa
/
Factores de Riesgo
/
Colonoscopía
/
Lactasa
/
Endoscopía
/
Alelos
/
Genotipo
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Annals of Coloproctology
Año:
2017
Tipo del documento:
Article