Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis
Korean Circulation Journal
;
: 160-167, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-59352
ABSTRACT
Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely coordinated by the genetically-primed program that is revealed by the sequential expression of transcription factors. It is important to investigate how spatial allocation of the heart containing cardiomyocytes and other mesoderm-derived cells is determined. In addition, the molecular mechanism underlying cardiomyocyte differentiation still remains elusive. The location of ectoderm-, mesoderm-, and endoderm-derived organs is determined by their initial allocation and subsequent mutual cell-cell interactions or paracrine-based regulation. In the present work, we provide an overview of cardiac development controlled by the germ layers and discuss the points that should be uncovered in future for understanding cardiogenesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Transcripción
/
Pez Cebra
/
Aborto Espontáneo
/
Cilios
/
Miocitos Cardíacos
/
Desarrollo Embrionario
/
Estructuras Embrionarias
/
Estratos Germinativos
/
Corazón
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Korean Circulation Journal
Año:
2017
Tipo del documento:
Artículo
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