Progress on diagnosis and intervention method for age-related sarcopenia / 中国组织工程研究

ABSTRACT

Sarcopenia is closely related with age-related loss of muscle fiber, reduced physical activity, hormone level decline and nutrition deficiency. Though torque generation in knee extension, relative skeletal muscle index, lean body weight, electromyogram, gait analysis, grasp force, nuclear magnetic resonance and B ultrasonic examination are generally accepted as diagnostic method, there is not an unified standard in diagnosis. Through the physical activity and diet can prevent and reverse the tendency of sarcopenia, which also improve the activity of the hypothalamic-GH-insulin-like growth factor-1 axis. In future, the characteristic therapy of Chinese medicine science can be added into resistance exercise and nutrition method, or combined compound hormones with nutrition intervention to design orthogonal test for seeking the best interaction, and explore the long-term safety and effectivity by follow-up observation.