The Efficacy of Infliximab in Refractory Uveitis
Journal of the Korean Ophthalmological Society
;
: 50-55, 2016.
Artículo
en Coreano
| WPRIM
| ID: wpr-59404
ABSTRACT
PURPOSE:
To investigate the effectiveness of infliximab as treatment for refractory uveitis that recurred in spite of immunosuppressive agents.METHODS:
Thirty patients who were treated for refractory uveitis from 2002 to 2011 were included in this study. We retrospectively reviewed the medical records of 15 patients who were treated with Infliximab and 15 patients not treated with Infliximab. Infliximab was injected intravenously (5 mg/kg) 3 times every 4 weeks, and the patients were followed-up at 1 week, 2 weeks, and every month thereafter. Anterior chamber cell reaction with a score greater than 0.5+ was defined as recurrence of uveitis.RESULTS:
Among 15 patients treated with Infliximab, only one showed no response to the medication. The recurrence rate was significantly higher in patients receiving Infliximab treatment (1.1 +/- 0.2 times) than in those not receiving Infliximab treatment (3.1 +/- 0.3 times) (p=0.022).CONCLUSIONS:
Infliximab can be used effectively on patients with refractory uveitis. However, a future prospective randomized study is needed to demonstrate the effectiveness of Infliximab and to determine an accurate protocol regarding dosage and number of injections.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Uveítis
/
Registros Médicos
/
Estudios Prospectivos
/
Estudios Retrospectivos
/
Factor de Necrosis Tumoral alfa
/
Infliximab
/
Inmunosupresores
/
Cámara Anterior
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio observacional
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Año:
2016
Tipo del documento:
Artículo
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