Reference values of fraction excretion of uric acid in healthy adults in Qingdao area

Xiaochen XU; Zhengju FU; Changgui LI

ABSTRACT

BACKGROUND:

The studies regarding reference values of fraction excretion of uric acid(FEUA)is poorly understood.

OBJECTIVE:

To establish reference values of FEUA in healthy adults in Qingdao area.DESIGN,TIME AND

SETTING:

The investigation and analysis was performed at the Qingdao Medical College from August 2007 to August 2008.

PARTICIPANTS:

A total of 581 healthy adults with aged 20-70 years,including 279 male and 302 female stayed in Qingdao more than 5 years were selected from August 2007 to August 2008.The adults were divided into groups according to the ages.There were 61 adults in the group aged 21-30 years(32 male and 29 female);92 adults in the group aged 31-40 years(40 male and 52 female);173 adults in the group aged 41-50 years(82 male and 91 female);169 adults in the group aged 51-60 years(88 male and 81 female);and 86 adults aged more than 60-year-old(37 male and 49 female).

METHODS:

The uric acid and creatinine of fasting blood and 12 h urine taken and tested with Sysmex chemix-180 to calculate FEUA,the results were statistically analyzed by SPSS 16.0 software.MAIN OUTCOME

MEASURES:

①Comparison of general information and biochemical index.②Comparison of serum uric acid,FEUA in sexes and reference values of FEUA.③Comparison of serum uric acid,FEUA in different age groups.

RESULTS:

Serum uric acid in male was higher,but FEUA was lower than that of female,there were significant difference between different genders(P 0.05).The normal range of FEUA in female and male was 4.039%-10.613% and 3.447%-9.915%,respectively.

CONCLUSION:

The reference value of FEUA in healthy adults in Qingdao is preliminarily established.To provide evidence for hyperuricemia control and prevention,it is necessary to establish respective reference values of FEUA and prompting the excretion of uric acid for healthy male and female.