Differentiation of bone marrow mesenchyaml stem cells into insulin-secreting cells using gene transfection / 中国组织工程研究

ABSTRACT

Bone marrow mesenchymal stem cells is a new approach for diabetes treatment, it can transdifferentiate into insulin cells in vitro, that may overcome the shortage of human donor islets, avoid the immunological rejection and moral principle problems which are involved into the research of embryonic stem cells.Studies have shown that insulin gene and its other necessary gene can introduce into primary cells or other somatic stem cells directly in diabetes mellitus patients, such as hepatic cells, intestines epidermis K cells, fibroblast cells and liver tumor cells and so on.Thereby, it can be translated into insulin-secreting cells.At present, the main study direction internationally is how to import insulin gene into target cells effectively, and make it express in a physical model.