Association of Ala22/72Ser polymorphism in the catechol-O-methyltransferase gene with schizophrenia and preliminary functional exploration / 基础医学与临床
Basic & Clinical Medicine
; (12)2006.
Article
en Zh
| WPRIM
| ID: wpr-594801
Biblioteca responsable:
WPRO
ABSTRACT
Objective Define the association of the catechol-O-methyltransferase(COMT) gene single nucleotide polymorphism(SNP) Ala22/72Ser with schizophrenia(SCZ) in Northern Han population.Methods In 506 SCZ patients,the genotype of Ala22/72Ser of COMT gene was sequenced and typing by polymerase chain reaction(PCR)-sequencing;the severity of psychiatric symptoms of SCZ patients was scaled by positive and negative syndrome scale(PANSS);the expression of COMT gene was determined by Real-Time PCR.Results In SCZ patients,the overall score of positive scale and general psychopathology scale were significantly increased in Ser and Ser/Ala carriers(P
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WPRIM
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Zh
Revista:
Basic & Clinical Medicine
Año:
2006
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Article