Surveillance of Drug Resistance of Coagulase-negative staphylococci / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To study the information of drug resistance of 1292 coagulase-negative staphylococci(CNS) isolates. METHODS There were 1292 isolates of CNS obtained from clinical patients in between 2001-2006.K-B test was used to determine the susceptibility and the results were read based on Clinical and Laboratory Standards Institute(CLSI) of the USA. RESULTS The isolating rate of CNS isolates was decreasing from 11.0% in the year of 2001 to 6.4% in the year of 2006.During the six years,the resistant rate to erythromycin,oxacillin and benzylpenicillin was high(90.0%,78.9% and 95.0%,respectively) and the resistant rate to cefepime,ciprofloxacin and levofloxacin increased from 17.3%,42.4%,and 28.7% in the year of 2001 to 39.1%,56.0% and 42.6% in the year of 2006.But the resistant rate to tetracycline,trimethoprim/sulfamethoxazole decreased from 71.2% and 72.0% in the year of 2001 to 52.7% and 33.3% in the year of 2006.The resistant rate to quinupristin /dalfopristin was 5.6%. CONCLUSIONS The steady resiatence rate of CNS over the past six years provides powerful evidence for the choice of clinical medication and practice of infection control.