Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders
Annals of Rehabilitation Medicine
;
: 340-346, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-59512
ABSTRACT
OBJECTIVE:
To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualified parent/caregiver-administered questionnaires.METHOD:
A total of 17 patients (age 7.6+/-4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance.RESULTS:
DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value.CONCLUSION:
Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and effective method to treat sialorrhea in children with neurologic disorders.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glándula Parótida
/
Glándulas Salivales
/
Sialorrea
/
Sorbitol
/
Toxinas Botulínicas
/
Tiramina
/
Estudios de Seguimiento
/
Toxinas Botulínicas Tipo A
/
Enfermedades del Sistema Nervioso
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Investigación cualitativa
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Annals of Rehabilitation Medicine
Año:
2012
Tipo del documento:
Artículo
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