Multidrug Resistance of Acinetobacter baumanii and Homogeneous Analysis / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To understand the drug-resistant status of Acinetobacter baumanii and provide scientific basis for infection treatment.METHODS Eight multidrug-resistant A.baumannii(MDR-AB) strains isolated from nosocomial inpatients in intensive care unit(ICU) were collected in May 2007 and tested for drug sensitivity and MIC determination as well.We typed A.baumannii isolates with pulsed-field gel electrophoresis(PFGE) to determine whether they derived from the same clone.RESULTS Four isolates from nosocomial inpatients were resistant to multiple antibiotics including carbapenem.The PFGE types identified from eight isolates were same.All A.baumannii isolates are closely related.CONCLUSIONS The prevalence of nosocomial infection is due to transmission of the same strains among the patients in ICU.This finding highly suggests that isolate 1 was the source of this nosocomial infection and the problem of hand hygiene maybe the main transmission route.