Study on synthesis on 7anpha-pregn-11beta, 17beta-diol-4-en-3-on-20-yne from 11beta-hydroxy-androstendion-3,17

ABSTRACT

From androst- 4,9(11)-dien-3,17-dion the synthesis of ethynylsteroid 17 alpha-pregn-11beta, 17-beta-diol-4-en-3-on20-yn was performed with a productivity of 68%. The 17 alpha-ethynylzition gave a productivity of 90%. The by product is 4% of 17 beta- ethynylization product. The product was identified by melting point, IR spectrum, proton magnetic resonance spectrum and mass spectrum