Leptin as a Potential Target for Estrogen Receptor-Positive Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
;
: 138-145, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-59654
ABSTRACT
PURPOSE:
Leptin is a potent adipokine that plays a significant role in tumor development and the progression of breast cancer. The aim of this study was to evaluate whether leptin affects the response to tamoxifen treatment in estrogen receptor (ER)-positive breast cancer cells.METHODS:
Leptin, leptin receptor (Ob-R), and activation of signaling pathways were studied by Western immunoblotting. The effects of leptin on tamoxifen-dependent growth inhibition were studied in MCF-7 and T-47D cells.RESULTS:
Leptin was expressed in MCF-7 and T-47D and had a proliferative effect on MCF-7 cells. Leptin significantly inhibited the antiestrogenic effect of tamoxifen in both cells only under beta-estradiol (E2) (20 nM) conditions. In MCF-7, the inhibitory effect against tamoxifen was a result from the activation of the ERK1/2 and STAT3 signal transduction pathway.CONCLUSION:
Leptin interferes with the effects of tamoxifen under E2 stimulated conditions in ER-positive breast cancer cells. These results imply that inhibition of leptin is expected to enhance the response to tamoxifen in ER-positive breast cancer cells, and, therefore, could be a promising way to overcome endocrine resistance.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamoxifeno
/
Mama
/
Neoplasias de la Mama
/
Transducción de Señal
/
Western Blotting
/
Moduladores de los Receptores de Estrógeno
/
Leptina
/
Estrógenos
/
Adipoquinas
/
Receptores de Leptina
Idioma:
Inglés
Revista:
Journal of Breast Cancer
Año:
2013
Tipo del documento:
Artículo
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