Randomized Controlled Study on the Effects of Intensive Cyclophosphamide Therapy Plus Corticosteroids and Corticosteroids-alone Treatment for Lupus Nephritis / 药物流行病学杂志

ABSTRACT

To investigate the short and long-term effects of intensive cyclophosphamide therapy plus corticosteroids on lupus mephritis, 27 patients with severe lupus nephritis were divided into two groups. Patients in group 1 received prednisone alone and patients in group 2 were given intensive cyclophosphamide therapy plus corticosteroids. The treatment course lasted for 1.5 years and the patients were followed up for 4 years. At the end of the treatment, the differences in indicators, single or comprehensive, of effieacy were statistically signifieant(P＜0.05) between the two groups. A four-year follow-up showed that the difference in relapse was significant(P＜0.05). It is concluded that the intensive cyclophosphamide therapy plus corticosteroids on lupus nephritis was better than that of predinison-alone treatment in our series in terms of short-term and long-term effects on lupus nephritis.