13C-Urea breath test and Helicobacter pylori infection and gastric inflammation in histological change / 国际儿科学杂志

ABSTRACT

Objective To investigate the correlation about the quantitative test result of 13C-urea breath test(13C-UBT) with the quantity of Helicobacter pylori( H.pylori) and the degree of gastric mucosal inflammation.Methods 13 C-UBT was tested in the children with upper gastrointestinal symptoms.Ninety-five cases of the children with positive result (DOBδ‰ ≥4.0) underwent endoscopy and gastroscopic biopsy.The correlation was analyzed between the result of the 13 C-UBT and the severity of gastric H.pylori infection and gastric mucosal inflammation.Results There were significant differences about DOB values between the group with severe gastric H.pylori infection and the group with mild to moderate infection ( P ＜ 0.05 ),the same result was observed between the group with severe gastric mucosal inflammation and the group with mild to moderate inflammation( P ＜ 0.05 ).There was certain correlation between DOB value and the amount of gastric H.pylori colonization and mucosal inflammation.Conclusion The quantitative test result of 13C-UBT could indicate the number of gastric H.pylori colonization,but lack a precise quantitative relationship between them.There was positive correlation between the DOB values and the degree of gastric inflammation.