Influence of percutaneous coronary intervention on plasma levels of monocyte chemotactic factor-1 and interlekin-6 in patients with coronary heart disease / 心血管康复医学杂志

ABSTRACT

Objective: To investigate influence of percutaneous coronary intervention (PCI) on inflammatory indexes and postoperative vascular restenosis in patients with coronary heart disease (CHD) through measuring plasma levels of monocyte chemotactic factor-1 (MCP-1) and interlekin-6 (IL-6) before and after PCI. Methods: A total of 60 CHD patients undergoing PCI with single vessel coronary disease were consecutively enrolled as PCI group, and 30 subjects with normal coronary artery proved by coronary angiography (CAG) were regard as normal control group. Enzyme linked immunosorbent assay (ELISA) was used to measure plasma MCP-1 and IL-6 levels before and after PCI，CAG in PCI group，normal control group respectively. Results: Compared with before PCI, there were significant increase in plasma levels of MCP-1 [(17.38±4.58) pg/L vs. (20.51±4.61) pg/L] and IL-6 [(14.59±4.62) pg/ml vs. (18.87±4.92) pg/ml] after operation in PCI group (P0.05). The MCP-1 and IL-6 levels after PCI in PCI group were significant more than those of normal control group after CAG (P<0.05). Conclusion: Plasma levels of MCP-1（plays a core regulative role in inflammatory reaction）and IL-6（a central adjustment factor in inflammatory response）increased in patients with coronary heart disease after PCI, suggesting MCP-1 and IL-6 correlate with in-stent restenosis after PCI．