Study on the relationship of carotid artery atherosclerosis and helicobacter pylori infection in patients with essential hypertension / 中国医师杂志

ABSTRACT

Objective To study the correlation of carotid artery atherosclerosis (CAS) and helicobacter pylori (Hp) infection in patients with essential hypertension (EH) by observing the carotid intima-media thickness (CAIMT),helicobacter pylori (Hp)-IgG antibody,blood lipid,high sensitive C-reactive protein (hs-CRP),and homocysteine(HCY).Methods To measure CAIMT,blood lipid,serum Hp-IgG antibody,hs-CRP,and HCY were measured by color doppler ultrasound instrument,and Hp-IgG antibody by colloidal gold method.Results A total of 150 EH patients were randomly divided into CAIMT and Hp-IgG-antibody groups,and were taken statistical analysis.Results There were 89 patients with EH CAIMT ＞ 1.0 mm(59.3％) as the intimal thickening,and 67 cases of Hp-IgG antibody(+) (44.7％) for Hp infection.CAIMT thickening (73.1％) in the Hp infection group was significantly higher than that of Hp infection group (48.2％) (P ＜0.05).In the thickened CAIMT group,Hp infection (55.1％) was significantly higher than that of CAIMT non thickening (29.5％) (P ＜0.05).EH patients complicated with CAIMT thickening and Hp infection had significant correlation (r =0.179,t =2.213,P ＜0.05).In the Hp infection group,the levels of serum triglyceride (TG),total cholesterol(TC),low density lipoprotein cholesterol (LDL-C),HCY,and hs-CRP were significantly higher than those of Hp infection group (P ＜ 0.05).Serum high density lipoprotein cholesterol (HDL-C) were significantly lower than those of the Hp infection group (P ＜ 0.05).Conclusions The study proved the correlation of CAS and Hp infection in patients with EH,and promoted the development of CAS probably by influencing the blood lipid metabolism,inflammatory reaction and HCY levels.It would be one of the treatment of EH with CAS by removing or prevention of Hp infection.