Liver Cirrhosis Due to Autoimmune Hepatitis Combined with Systemic Sclerosis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 48-52, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-59912
ABSTRACT
Systemic sclerosis (SSc) is a chronic systemic disease that affects the skin, lungs, heart, gastrointestinal tract, kidneys, and musculoskeletal system. Although up to 90% of patients with scleroderma have been estimated to have gastrointestinal involvement, liver disease has been reported only rarely. A 51-year-old woman was hospitalized due to esophageal variceal bleeding. Her serum was positive for anti-nuclear antibody and anti-centromere antibody. Sclerodactyly was noted on both hands, and she had recently developed Raynaud's syndrome. Punch biopsy of the hand showed hyperkeratosis, regular acanthosis, and increased basal pigmentation in the epidermis, and thick pale collagenous bundles in the dermis. Liver biopsy showed chronic active hepatitis with bridging fibrosis. Consequently, she was diagnosed with liver cirrhosis due to autoimmune hepatitis (AIH) combined with SSc. AIH had subsided after administration of prednisolone at 40 mg per day. She received 5-10 mg/day of prednisolone as an outpatient, and her condition has remained stable. Patients with either AIH or SSc should be monitored for further development of concurrent autoimmune diseases. The early diagnosis of AIH combined with SSc will be helpful in achieving optimal management.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Raynaud
/
Esclerodermia Sistémica
/
Piel
/
Prednisolona
/
Várices Esofágicas y Gástricas
/
Anticuerpos Antinucleares
/
Hepatitis Autoinmune
/
Hemorragia Gastrointestinal
/
Cirrosis Hepática
/
Antiinflamatorios
Tipo de estudio:
Estudio de tamizaje
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
The Korean Journal of Gastroenterology
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS