Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
Biomolecules & Therapeutics
; : 284-289, 2013.
Article
en En
| WPRIM
| ID: wpr-59931
Biblioteca responsable:
WPRO
ABSTRACT
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
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Texto completo:
1
Índice:
WPRIM
Asunto principal:
Plantas
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Glucemia
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Anafilaxis Cutánea Pasiva
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Muerte Celular
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Técnicas de Cultivo de Célula
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Zea mays
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Células Secretoras de Insulina
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Polifenoles
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Insulina
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Antocianinas
Límite:
Animals
Idioma:
En
Revista:
Biomolecules & Therapeutics
Año:
2013
Tipo del documento:
Article