Correlation between levels of plasma homocysteine and fibrinogen with cerebral infarction and prognosis / 国际检验医学杂志

ABSTRACT

Objective To study the correlation between the change of plasma homocysteine (Hcy)and fibrinogen(Fib)levels with the disease condition and prognosis in the patients with cerebral infarction(CI).Methods The plasma levels of Hcy and Fib were detected in 250 cases of cerebral infarction and 100 healthy adults(normal control,NC).All patients were evaluated on 1 d af-ter admission by NHISS,and after the 6-month follow-up by the modified Rankin scale.Results The levels of plasma Hcy and Fib in the CI group were significantly higher than those in the NC group(P <0.05);the levels of plasma Hcy and Fib in the NHISS se-vere patients were higher than those in the moderate and mild patients (P <0.05);the levels of plasma Hcy and Fib in the moderate patients were significantly higher than those in the mild patients (P <0.05).The good prognosis rate the low Hcy and Fib group was significantly higher than that in high Hcy and Fib group (P <0.05).Conclusion The levels of plasma Hcy and Fib are signifi-cantly increased in the patients with CI,and the increase in the severe patients is more significant.The patients with increased plas-ma Hcy and Fib levels have relatively poor prognosis.