Behavioral effects of early-life social isolation on adult rats / 军事医学
Military Medical Sciences
;
(12): 791-794,822, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-600232
ABSTRACT
Objective To investigate rats reared in social isolation as a model of behavioral symptoms of neurodevelop-mental psychiatric disorders including schizophrenia.Methods Male rat pups were housed in individual cages from post-weaning to adulthood.Locomotor activity detection, Morris water maze test and social interaction test were performed. Results Compared with controls, the social isolation-reared rats got more body mass, showed locomotor hyperactivity and increased social interaction, but significant spatial learning changes were not observed in Morris water maze test.Conclu-sion Exposing rats to social isolation can profoundly affect behavior in adulthood, which can be used to build animal mod-els of neurodevelopmental psychiatric disorders including schizophrenia.
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Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Military Medical Sciences
Año:
2014
Tipo del documento:
Artículo
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