Investigation about atorvastatin resist to tobacco smoking inducing endothelial inflammation / 重庆医学
Chongqing Medicine
; (36): 2616-2617,2620, 2015.
Article
en Zh
| WPRIM
| ID: wpr-600362
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the role of atorvastatin resist to tobacco smoking inducing endothelial inflammation .Meth‐ods HUVECs were divided into normal control group ,cigarette smoking extract(CSE) group and atorvastatin(AS)+CSE group . The cellular morphology of HUVECs in three group were observed ,then the expressions of VCAM‐1 and E selectin in HUVECs in three group were detected by western blot assay .Results In CES group ,drastic morphological change of HUVECs were observed . In AS+CSE group ,minor morphological change of HUVECs were observed .Also ,the protein levels of VCAM‐1 and E selectin were much higher in CSE group than that of in other two groups(P<0 .05) ,and the protein levels of VCAM‐1 and E‐selectin in AS+CSE group were a little higher than that of in control group ,but much lower than that of in CSE group(P<0 .05) .Conclusion Our results showed that atorvastatin might partly resist to tobacco smoking inducing endothelial inflammation .
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WPRIM
Idioma:
Zh
Revista:
Chongqing Medicine
Año:
2015
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Article