Comparison of the influence and the effect for lipid level of rosuvastatin with atorvastatin in the treatment of coronary heart disease / 中国基层医药

ABSTRACT

Objective To investigate the influence and the efficacy for lipid level of rosuvastatin with atorv-astatin in the treatment of coronary heart disease.Methods 160 patients with coronary heart disease were randomly divided into the observation group and the control group,80 cases in each group.The patients of the observation group were given rosuvastatin 10mg every night,the control group were treated with the same dose of atorvastatin every night,the efficacy before and after treatment were compared after continuous 21d,and the lipid changed of the two groups were compared.Results There were statistically significant difference in the lipid level of the observation group before and after treatment(t =3.728,4.516,5.322,3.143,all P <0.05),and after treatment the TC,TG,LDL-C levels of the observation group were lower than those of the control group,the HDL -C level was higher than that of the control group,the difference was statistically significant(t =3.512,5.529,6.325,3.139,all P <0.05);There were statistically significant differences in hs -CRP,Hcy,IMT of the observation group before and after treatment [(14.35 ±1.56)μmol/L vs (22.45 ±1.82)μmol/L,(0.31 ±0.03)g/L vs (0.45 ±0.06)g/L,(1.64 ±0.11)mm vs (2.03 ±0.12)mm](t =3.728,3.231,3.452,all P <0.05),and the hs -CRP,Hcy,IMT of the observation group were lower than those of the control group[(14.35 ±1.56)μmol/L vs (16.56 ±1.26)μmol/L,(0.31 ±0.03)g/L vs (0.38 ±0.05)g/L,(1.64 ±0.11 )mm vs (1.81 ±0.12)mm](t =3.512,3.529,4.325,all P <0.05 ). Conclusion The treatment effect and lipid level of rosuvastatin was superior to atorvastatin.