Curative effect of ganglioside combined with hyperbaric oxygen in treatment of neonatal hypoxic ischemic encephalopathy and its influence on serum NSE / 中国基层医药

ABSTRACT

Objective To investigate the curative effect of ganglioside combined with hyperbaric oxygen in treatment of neonatal hypoxic ischemic encephalopathy (HIE)and its influence on serum neuronspecific enolase (NSE).Methods 92 cases of children with HIE were randomly divided into two groups,each group in 46 cases. They were all given routine therapy,and added the citicoline for treatment at third day after being hospitalized,and the observation group were treated with ganglion ganglioside combined with hyperbaric oxygen on the basis of that.Clinical treatment effect and neonatal behavioral neurological(NBNA)scores,serum neuron specific enolase (NSE)levels of the two groups before and after treatment were observed and compared.Results The total effective rate of the obser-vation group was 93.48%,which was significantly higher than 76.09% of the control group (χ2 =10.02,P <0.05);NBNA score of the observation group after treatment were (38.92 ±4.10)points,which was significantly higher than that before treatment (t =8.00,P <0.05)and the control group (t =6.89,P <0.05);while its serum NSE was (9.56 ± 2.03)μg/L,which was significantly lower than before treatment(t =8.31,P <0.05)and the control group(t =7.12, P <0.05).Conclusion The ganglioside combined with hyperbaric oxygen therapy has a significant effect for hypoxic ischemic encephalopathy,which can significantly decrease the serum NSE level,improve neurological function and has a better clinical application value.