A Meta analysis of the cancer incidence of children conceived by assisted reproductive technology / 重庆医学

ABSTRACT

Objective To evaluate the incidence of cancer in children born with assisted reproductive technology (ART ) . Methods The literatures were obtained by computer through EBSCO full‐text database ,Pubmed ,Germany Springer journal data‐base ,Cochrane Libarary ,Chinese academic journals published in the pool of network (CNKI) ,Wanfang and Veipu Chinese Journal Full‐text databases ,and other search methods .ART and child health natural pregnancy cohort study were included .The Meta‐anal‐ysis was conducted by using RevMan5 .0 software .Results Sixteen studies were included according to the criteria ,and 89 894 cases of ART‐born offspring were collected .The results of Meta analysis revealed that there was no significant difference between ART and non‐ART children on the incidence of tumor (OR= 1 .85 ,P> 0 .05) .Conclusion This study showed that the probability of ART offspring suffering from malignant is basically the same with non‐ART children ,but the potential long‐term risks are not yet clear .