Correlation among serum APN, HO-1 concentrations and severity of coronary lesion in patients with acute coronary syndrome / 心血管康复医学杂志

ABSTRACT

Objective: To analyze the correlation among serum adiponectin (APN), heme oxygenase-1 (HO-1) concentrations and severity of coronary lesion in patients with acute coronary syndrome (ACS). Methods: A total of 78 ACS patients, who hospitalized and received therapy in our hospital from Oct 2013 to Oct 2014, were enrolled as ACS group. According to severity of coronary lesion, they were further divided into single vessel coronary disease group (single vessel group, n=15), double-vessel coronary disease group (double-vessel group, n=37) and multi-vessel coronary disease group(multi-vessel group, n=26). Another 72 subjects without coronary heart disease (CHD), who received physical examination in our hospital during the same period, were selected as non-CHD control group. Serum concentrations of APN and HO-1 were measured in all groups. The correlation among serum APN, HO-1 concentrations and severity of coronary lesion were analyzed. Results: Compared with non-CHD control group, there were significant reductions in serum concentrations of APN [(15.27±2.31) mg/L vs. (5.73±0.88) mg/L] and HO-1 [(55.09±8.63) μg/L vs. (23.17±3.09) μg/L] in ACS group, P<0.01 both. Compared with single vessel group, there were significant reductions in serum concentrations of APN[(9.72±1.13) mg/L vs. (7.05±0.93) mg/L vs. (4.23±0.52) mg/L] and HO-1 [(38.16±7.52) μg/L vs. (28.17±5.31) μg/L vs. (20.32±3.28) μg/L] in double-vessel group and multi-vessel group, and those of multi-vessel group were significantly lower than those of double-vessel group, P<0.05 or <0.01. Linear regression analysis indicated that serum concentrations of APN and HO-1 were significant inversely correlated with severity of coronary lesion (r=-2.869, -2.742, P<0.05 both). Conclusion: Serum concentrations of APN and HO-1 significantly reduce in ACS patients, and their levels are significant inversely correlated with severity of coronary lesion, so they are helpful to judging patient’s condition and guiding treatment.