Analysis of curative effect of tripterygium on NOD mice and possible mecha-nisms / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 1524-1527,1531, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-602599
ABSTRACT
Objective:
To analyze the curative effect of tripterygium on NOD mice and the possible mechanisms.Methods:
NOD mice were divided into 2 groups,Group Atripterygium treatment(0.07 mg/kg,intraperitoneal injection,12 weeks);Group Bsaline control.BALB/c mice were enrolled as control group( Group C).Results:
After experiment,Group A had lower salivary flow rate than these of Group C,but higher than these of Group B at 12 and 20 weeks old( P<0.05).Group A had higher rate of inflammatory cells apoptosis than these of Group B and Group C(P<0.05).Group A mice had lower levels of TNF-α,IL-6 and IL-1βthan these of Group B(P<0.05),but higher than these of Group C(P<0.05).Group A mice had a higher level of SHIP-1 but a lower level of Mir-155 than these of Group B mice(P<0.05).Group A mice had a better neuroelectrophysiological outcomes than these of Group B mice ( P<0.05).Conclusion:
Tripterygium can meliorate the sailoadentitis of NOD mice,which may though activating the SHIP-1/Mir-155 signaling pathway.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Immunology
Año:
2015
Tipo del documento:
Artículo
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