Noninvasive Detection of Liver Fibrosis by Fibroscan in Asymptomatic Carriers with Chronic Hepatitis B Virus / 华中科技大学学报(医学版)

ABSTRACT

Objective To investigate the clinical application of Fibroscan to noninvasive detection of liver fibrosis in asymp‐tomatic carriers(ASCs)with chronic hepatitis B virus(HBV).Methods Clinical data of 195 chronic HBV ASCs were retrospec‐tively analyzed ,including liver function ,HBV DNA quantitation ,liver stiffness(LS) ,color Doppler ultrasound results of the liver and spleen and histopathological findings of the liver.LS was evaluated by transient elastography(Fibroscan).Liver biopsy was performed in 80 carriers for histological examination.Results The LS value was(6.22 ± 2.50)kPa in 195 cases.There was no significant difference in the LS value between HBV DNA 15 years was significantly higher than that in patients with HBV carrying dura‐tion≤5 years(P<0.01).It was (6.72 ± 2.33) kPa in patients(n=49)with liver tissue inflammation and necrosis patients(n=31)with liver tissue inflammation and necrosis ≥G2 or fibrosis ≥S2 ,with significant difference found between the two groups(P<0.01).Conclusion Dynamic surveillance of liver fibrosis by Fibroscan in chronic HBV ASCs facilitates monitoring the occurrence of liver fibrosis ,and it is helpful to establish the optimal timing for a liver biopsy for HBV ASCs.