Application of serum procalcitonin test in diagnosis of neonatal bacterial infectious diseases / 国际检验医学杂志

ABSTRACT

Objective To investigate the diagnostic value of procalcitonin(PCT) in bacterial infectious diseases for newborns . Methods Using enzyme‐linked immune fluorescence analysis technology to determine PCT of 90 samples of neonatal serum .The Observation group(48 cases) and control group(42 cases) were grouped according to the gold standard which were microbial cul‐ture result of sterile body fluid and clinical diagnosis .Recorded the values of PCT ,WBC ,CRP and IL‐6 detected in the same period , then calculate the sensitivity and specificity ,and draw the ROC curve to compare sensitivity and specificity between PCT and the other infectious indicators .Results The sensitivity and specificity of PCT were 87 .50% and 85 .71% respectively ,the positive pre‐dictive value(PPV) and negative predictive value(NPV)of it were 87 .50% and 85 .71% .However ,the sensitivity and specificity of CRP were 81 .25% and 83 .33% ,the PPV and NPV of it were 84 .78% and 79 .54% .The sensitivity and specificity of WBC were 68 .75% and 57 .14% ,the PPV and NPV of it were 64 .70% and 61 .53% .The sensitivity and specificity of IL‐6 were 93 .75% and 71 .43% ,the PPV and NPV of it were 78 .95% and 90 .91% .In addition to that ,the area under the ROC of PCT ,CRP ,IL‐6 and WBC ,which were 0 .859 ,0 .852 ,0 .803 and 0 .647 respectively .Conclusion Compared with the other 3 infectious indicators ,PCT has high sensitivity and specificity in the diagnosis of neonatal bacterial infection diseases .Moreover ,the detection method of PCT is simple and feasible ,PCT could also provide laboratory basis for the diagnosis .