Determination of Residual Organic Solvents in Imported Lidocaine Patches by GC / 中国药师
China Pharmacist
;
(12): 377-378,379, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-603457
ABSTRACT
Objective:
To establish a GC method for the determination of residual organic solvents in lidocaine patches.Methods:
GC was carried out on a DB-WAX capillary column (30 m × 0. 25 mm, 0. 5 μm). The detector was FID and the carrier gas was He. The initial temperature was 50℃, maintained for 8 min, and then raised to 250℃ with a rate of 50℃ per min. The inlet temperature and the detector temperature were 280℃. The separation was 50 ∶1.Results:
The linear range of acetone, ethyl acetate and methanol was 15. 0-600. 0 μg·ml-1. The average recovery was 97. 4% (RSD =3. 2%, n=9), 95. 6% (RSD=1. 9%, n=9) and 112. 0%(RSD =4. 5%, n=9), respectively.Conclusion:
The method is simple and accurate,which can be used for the determination of re-sidual organic solvents in lidocaine patches.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacist
Año:
2016
Tipo del documento:
Artículo
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