Observation of the efficacy of ganglion glycosides in the treatment of elderly patients with Parkinson's disease and its influence on the serum tumor necrosis factor-alpha / 中国基层医药

ABSTRACT

Objective To observe the efficacy of ganglion glycosides in the treatment of elderly patients with Parkinson's disease and its influence on the serum tumor necrosis factor -alpha(TNF -α).Methods 60 elderly patients with Parkinson's disease were selected,and according to the different treatments,they were randomly divided into the observation group(n =30)and control group(n =30).The control group was given routine treatment,and the observation group was given ganglion glycosides treatment on the basis of routine treatment.The comprehensive rating scale score changes were observed,and the curative effect,serum TNF -αlevel changes were compared between two groups.Results The total effective rate of the observation group was 53.3%,which was higher than 23.3% of the control group(χ2 =6.721,P <0.05).After treatment,Parkinson's disease rating scale score of the indexes (spirit, behavior,emotions and daily activities and motor function)of the two groups were significantly lower(t =3.571, 5.726,7.153,all P <0.05).The serum TNF -αconcentrations before and after treatment of the observation group were (27.4 ±6.1)μg/L,(13.1 ±3.4)μg/L,respectively,and those of the control group were (27.6 ±6.0)μg/L, (20.3 ±4.7)μg/L respectively.After treatment,the serum TNF -αlevels of the two groups were significantly lower than before treatment (t =5.614,8.352,all P <0.05 ),and after treatment,the serum TNF -α level of the observation group was significantly lower than that of the control group (t =4.241,P <0.05).Conclusion Ganglion glycosides in the treatment of elderly patients with Parkinson's disease can make slow markedly improved,lower levels of serum TNF -α,has significant clinical therapeutic effect.